Nov 21, 2022, 12:29 pm ET in NFL
Read Time: 3 min

Expert Top Pick of the Day: San Francisco 49ers vs. Arizona Cardinals

Top Pick of the Day

The 49ers and Cardinals matchup for tonight’s game as San Francisco looks for its third straight win. They’re 5-4 this season and can tie the Seattle Seahawks for first place in the division with a victory. The team has consecutive wins over the Los Angeles Chargers and the Rams after taking a 44-23 beating on the road against the Kansas City Chiefs.

Arizona is 4-6 on the season and in third place in the NFC West standings. They broke a two-game losing streak last week with a 27-17 victory over the Rams.

The Cardinals also welcome the chance to play at a neutral stadium in tonight’s game, as they’re just 1-4 at home this season. However, QB Kyler Murray and backup Colt McCoy are questionable for tonight’s game with injuries.


San Francisco 49er vs. Arizona Cardinals Schedule


  • Date: Monday, November 21, 2022
  • Time: 07:15 PM CST
  • Location: Estadio Azteca, Mexico City, MX


Niners Look To Stay Hot

The Niners have a solid offense this season with a lot of athletes that can make big plays. However, it was the defense that led the way in their last win against the Chargers, shutting them out in the second half. San Francisco seems to have turned around their defense since giving up 44 points on the road against the Kansas City Chiefs three weeks ago.

Jimmy Garoppolo has thrown for 1,931 yards and 11 touchdowns with four interceptions to lead the Niners’ offense. Christian McCaffrey has gained 170 yards rushing since coming over from Carolina in a trade a few weeks ago and is averaging 4.3 yards per carry.

Brandon Aiyuk is the leading receiver for San Francisco, with 44 receptions for 567 yards and two touchdowns.


Cards Desperately Need A Win

Arizona had much higher expectations when the season began but has been a disappointment in a season where they haven’t yet won two consecutive games.

They’ll have a chance to do that tonight against a defense that’s sixth in the league, giving up 18.1 points per game. McCoy will likely start tonight’s game but will have a considerable task in putting many points on the scoreboard.

Kyler Murray has thrown for 2168 yards and 12 touchdowns with six interceptions this season and is also the team’s leading rusher with 59 carries for 359 yards and two touchdowns. Marquise Brown is the leading receiver for Arizona with 43 catches for 485 yards and three touchdowns.


San Francisco 49ers vs. Arizona Cardinals Odds Comparison

The Niners are 1-7-1 against the spread in their last nine games against the Cardinals and are 9-2 in their previous 11 games against NFC opponents.

The total has gone under in four of the Cardinals’ last five games, and they are 1-6 in their previous seven games against NFC West rivals.


  • DraftKings has the 49ers at -450 on a spread of -10, and the total is 42.5. 
  • FanDuel has the 49ers at -480 on a spread of -10, and the total is 42.5.
  • Caesars has the 49ersat -455 on a spread of -10, and the total is 42.5.


Godds Pick or Prediction of the Game

The 49ers lead the Cardinals in most offensive categories and are now healthy at the quarterback position. They have also shut out their opponents in the second half for two straight games on defense.

Arizona will have to open up their offense and take more shots down the field if they hope to keep this game close.

Godds Pick/Prediction: The 49ers win, and the total stays under.