Houston Astros

Dustin Harris

LF

Harris had started in the Astros' first two games of the series and went 0-for-4 with a walk and two runs before being forced out of Tuesday's 8-5 loss in the bottom of the fifth inning after being hit in the left hand by a pitch in the top of the frame. Though the Astros have classified Harris' hand injury as a bruise, he's feeling sore enough that he'll be held out of the lineup Wednesday against a right-hander (Tanner Bibee). Houston will go with a starting outfield of Brice Matthews, Daniel Johnson and Cam Smith from left to right in the series finale.

Taylor Trammell

LF

Trammell suffered a left groin injury while running the bases Monday, and it sounds as though he'll require a trip to the injured list. An official move should come at some point Tuesday. Dustin Harris and Brice Matthews could see more time in center field while Trammell is sidelined.

Joey Loperfido

LF

Loperfido is with the team in Cleveland for its brief three-game road trip, which is a good omen for his prospects of a quick return. He will be eligible for activation from the 10-day injured list April 28.

Jeremy Pena

SS

It appears to be the first time Pena was cleared to run since he landed on the 10-day injured list a week ago with a Grade 1 right hamstring strain. Pena is eligible to return Friday, but it's possible the Astros will ask him to go out on a rehab assignment before being activated. Carlos Correa has been the team's primary shortstop since Pena went down, with Isaac Paredes handling third base.

Cody Bolton

RP

Bolton landed on the 15-day injured list last week with mid-back inflammation. He is eligible for activation April 28 and has a good chance to be back by that date, given that he's already been cleared to face hitters.

Tatsuya Imai

SP

It appears to be the first time he has thrown off the mound since landed on the 15-day injured list a week ago with right arm fatigue. The Astros haven't revealed the next steps for Imai, but it will likely involve facing hitters and perhaps making a rehab start or two. Imai holds a 7.27 ERA and 13:11 K:BB over his first 8.2 innings with Houston.

Nick Allen

SS

Allen was originally in Saturday's lineup but ultimately was unable to take the field. Original reports suggested he was available for Saturday's game, though it appears that likely wasn't the case. The severity of the issue is not clear.

Cristian Javier

SP

Javier's initial placement on the 15-day IL was retroactive to April 9, so his move to the 60-day IL ensures that he'll be on the shelf through at least the first week of June while he recovers from a Grade 2 right shoulder strain. Given the length of his absence along with his poor numbers prior to landing on the shelf (12.54 ERA, 2.36 WHIP and 4:9 K:BB in 9.1 innings over three starts), Javier likely won't be worth holding in the majority of fantasy leagues.

Nate Pearson

RP

Pearson has been on the shelf all season while he works his way back from an offseason cleanup procedure on his right elbow, but the fact that he's now faced on multiple occasions suggests that a rehab assignment could be on the horizon. Given that he didn't pitch in any games during the Grapefruit League, Pearson will likely require an extended minor-league assignment before being activated from the 15-day injured list and joining the Houston bullpen.

Hunter Brown

SP

Cristian Javier is facing a similar timeline for a return after both he and Brown sustained Grade 2 right shoulder strains within less than a week of one another. Shortly after Brown was diagnosed with the injury April 5, the Astros indicated that the right-hander would be shut down from throwing for two weeks before being re-evaluated, so he could be cleared to start playing light catch at some point in the coming days. Even so, Brown will be in line for a lengthy buildup, and a more definitive target date for his return won't become clear until he's ready to head out on what will likely be a multi-start minor-league rehab assignment.

Zach Dezenzo

LF

Dezenzo sustained a sprained elbow while playing for Team Italy in the World Baseball Classic last month. The 25-year-old appeared in 34 games for the Astros last season, slashing .245/.321/.367 with two homers, 10 RBI, 17 runs scored, one stolen base and an 11:37 BB:K across 109 plate appearances.

Josh Hader

RP

McTaggart notes that Hader was sitting 91-to-93 mph with his fastball during the live session, and says that given Hader's quotes about where he is in his recovery the southpaw is "perhaps about a month away from returning, without any setbacks." Hader, who is working his way back slowly from a bout of left biceps tendinitis, added, "I'm feeling good, feeling strong. I got through it throwing relatively hard and commanded the baseball in the zone, commanded the slider, getting good whiffs on it. Ideally, that's what you want." Meanwhile, Bryan Abreu has struggled in the ninth inning for the Astros this season, opening the door for Enyel De Los Santos to earn a couple saves in recent days.

Bennett Sousa

RP

Sousa opened the regular season on the injured list after suffering a left oblique strain during his final spring training appearance. It's unclear how many rehab outings he'll need, but the Astros never imagined the southpaw needing much more than a minimum-length IL stint, so he could be added to the big-league bullpen relatively soon.

Jake Meyers

CF

Meyers checked his swing on a Michael Lorenzen pitch but tweaked something in the process. He will likely be sent for an MRI to gain more clarity on the injury. Should Meyers have to miss time, Joey Loperfido and Brice Matthews are candidates for more playing time in center field.

Ronel Blanco

SP

The Astros made a flurry of roster moves Friday, and moving Blanco to the 60-day IL opened up a spot on the 40-man roster for J.P. France, per Chandler Rome of The Athletic. Blanco is recovering from Tommy John surgery that he underwent in June of 2025, so he won't be available for the Astros until the second half of the 2026 season.

Hayden Wesneski

SP

The Astros needed the spot on the 40-man roster for reliever Cody Bolton, who had his contract selected from Triple-A Sugar Land in a corresponding move. Wesneski is still working his way back from last May's Tommy John surgery.

Brandon Walter

SP

Putting Walter on the 60-day IL gives Houston another 40-man roster spot to play with. The lefty will miss the entire 2026 campaign after having Tommy John surgery last September.