Buffalo Bills

Christian Benford

CB

Benford suffered a toe injury during the third quarter of Sunday's Week 3 win over the Chargers and didn't return to the contest. With consecutive DNPs to begin the week of prep, the veteran cornerback's status for Sunday's matchup against the Patriots is looking very iffy. Should Benford not be able to suit up for that game, Davison Igbinosun could draw the start.

T.J. Sanders

DT

Sanders underwent surgery to have his appendix removed on Tuesday, Sept. 22, and he didn't play in Week 3 against the Chargers. The second-year pro didn't practice Wednesday to begin Week 4 prep, but he was able to participate in a limited capacity Thursday. That's a good sign Sanders is healing well, though it remains to be seen if he'll be ready to suit up Sunday versus New England.

Keon Coleman

WR

A spectator for the Bills' first Week 4 practice Wednesday, Coleman was able to take a step forward in activity a day later. The third-year wideout will likely need to upgrade to full activity to avoid carrying a designation into Sunday's game against the Patriots, but at this stage in the week, he appears to be trending toward playing.

Sam Franklin Jr.

S

questionable

Deone Walker

DT

DJ Moore

WR

Moore didn't practice much leading up to Buffalo's Week 3 win over the Chargers, but he proceeded to suit up and caught six of 10 targets for 67 yards in the victory. Per Sal Capaccio of WGR Sports Radio 550 Buffalo, the veteran wide receiver once again sported a no-contact jersey during Thursday's practice, but he still looks on track to play Sunday against the Patriots. If Moore can upgrade to full participation Friday, he'll likely avoid taking a questionable tag into the weekend.

C.J. Gardner-Johnson

S

Chargers quarterback Justin Herbert threw Gardner-Johnson a "meatball sub," according to commentator Tom Brady, early in the fourth quarter of Sunday's game at the Bills' one-yard line. The pick resulted in the Bills taking a lead for the first time in an eventual 24-16 win. Gardner-Johnson played 68 of the team's 69 defensive plays in the contest.

Greg Rousseau

LB

Rousseau leads the NFL with 6.0 sacks, having logged 2.0 sacks in each of the first three games of the 2026 regular season. The linebacker has had a stunning breakout since switching to defensive coordinator Jim Leonhard's 3-4 defense. The 26-year-old is entering his sixth NFL season and has begun to make a compelling early case that should put him on Defensive Player of the Year ballots if he can keep producing throughout the season.

Ar'maj Reed-Adams

G

The rookie seventh-rounder was not available for the Bills' Week 3 home game against the Chargers due to an elbow injury. Reed-Adams' full practice Wednesday indicates he'll suit up against the Patriots on Sunday to provide the Bills with depth on the offensive line.

Damar Hamlin

S

questionable

Joe Andreessen

LB

questionable

Josh Allen

QB

Allen played every snap in this past Sunday's 24-16 win over the Chargers, but he appeared to take a hard hit to his left knee at one point during the fourth quarter and looked to be in pain. Head coach Joe Brady spoke to the media Monday and downplayed any concern about Allen's availability heading into this Sunday's matchup with the Patriots, and the quarterback's presence on the field for the start of Week 4 prep supports the notion that he'll be ready to go for game day. Jay Skurski of The Buffalo News noted that Allen had no noticeable protection on his knee during individual drills Wednesday and seemed to be moving around without issue.

Dawson Knox

TE

Knox and fellow tight end Dalton Kincaid combined for only four targets from Josh Allen, with wide receiver DJ Moore leading all pass catchers with 10 targets. Knox is up to a 4-17-1 line on four targets through three games, and his production will be limited to occasional red zone opportunities as long as Kincaid is healthy. The Bills will stay home for an AFC East clash against the Patriots in Week 4.

Khalil Shakir

WR

Shakir played 71 percent of the Bills' offensive snaps in the contest but caught just one pass. The wide receiver was bullied in coverage while Josh Allen struggled on a day when the team's offense combined for five total turnovers.

Ray Davis

RB

Davis' catch for no gain early in the fourth quarter was negated by a holding penalty by Alec Anderson. It appears Davis will not be a factor in the Bills' offensive game plan this season, with Ty Johnson serving as the backup option in the backfield for James Cook. Davis should continue to see the field as a contributor on special teams, though he did not return a kickoff after doing so in both of the first two games of the regular season.

Tyler Bass

PK

The Bills finally got on the scoreboard at the 6:02 mark of the second quarter on a 28-yard, chip-shot field goal by Bass, with the veteran kicker making each of his next three extra-point attempts. He's made all four of his field-goal tries (all within 50 yards) and has gone 11-for-12 on PATs through three regular-season games, and his scoring floor should be elevated week-to-week as long as Josh Allen is running the Bills offense. Buffalo wraps up its three-game homestand in a Week 4 AFC East showdown against New England.

Mike Danna

DE

Skyler Bell

WR

Jude Bowry

OT

Jalon Kilgore

S

Dalton Kincaid

TE

Kincaid finished third in receptions and receiving yards on the afternoon for the Bills and tied for the same slotting in targets, but the tight end's downturn in production compared to the first two weeks stood out. He had opened the season with a combined 12-125-1 line on 14 targets, but the Chargers appeared to key on slowing him down Sunday and also forced the ball from him at the end of a 24-yard catch late in the third quarter for Kincaid's first lost fumble since his 2023 rookie campaign. Despite the relatively quiet performance, Kincaid should remain a key figure in the air attack during a Week 4 home matchup against the Patriots next Sunday.

James Cook III

RB

Although neither offense looked anywhere close to cohesive as a whole, Cook was a rare exception. The star running back delivered another dominant performance on the ground despite his day getting off on the wrong foot, as he lost a fumble on the first play from scrimmage and saw the Chargers parlay it into a touchdown. Cook's longest run of the day was a relatively modest 23 yards, meaning he consistently ripped off chunk gains against the Chargers defense. He also went in for his second touchdown of the season at a critical juncture in the fourth quarter, extending a 17-13 Bills lead at the time with a three-yard run. Cook has quickly amassed 346 rushing yards at 6.0 yards per carry over his first three games, affording him an abundance of momentum heading into a Week 4 divisional home showdown against the Patriots next Sunday.

Dorian Williams

LB

Ed Oliver

DT

Oliver didn't play in the Week 2 win over Detroit due to a hip injury. However, despite carrying a questionable tag for the Week 3 meeting with the Chargers, the veteran will be back on the field, likely resulting in less work for DeWayne Carter.

Jordan Hancock

CB

Hancock likely suffered his hamstring injury in the Bills' Week 2 win over the Lions. The issue appears to be significant, leading the team to move Hancock to IR. The defensive back will need to miss at least four games before becoming eligible to return to the Bills' active roster. The team signed Greg Dortch from the practice squad to the active roster in a corresponding move.