San Francisco 49ers

Gracen Halton

DT

Halton did not return to the 49ers' Week 3 win over the Cardinals due to an ankle injury. However, his absence from Wednesday's injury report indicates that his ankle is fine, and the rookie fourth-rounder should be available for Sunday's home game against the Broncos. Halton has eight tackles (five solo) and one pass defense through the first three games of the regular season.

Dre Greenlaw

LB

Greenlaw injured his quad during the fourth quarter of the 49ers' 36-30 win over the Cardinals in Week 3, when he logged eight tackles (three solo). The veteran linebacker will need to return to practice in at least a limited capacity over the coming days to have a realistic chance of playing against the Broncos on Sunday. If Greenlaw is unable to play, then Garret Wallow would likely start alongside Fred Warner and Jaden Dugger at linebacker.

KhaDarel Hodge

WR

Hodge may have tweaked his knee during the 49ers' 36-30 win over the Cardinals in Week 3, when he played 54 offensive snaps without seeing a target from Brock Purdy. Hodge will have two more opportunities to log a full practice and avoid an injury designation ahead of Sunday's game against the Broncos.

Mykel Williams

DE

Williams spent his first practice back with the 49ers as a limited participant. The team has until Oct. 21. to add the linebacker to the 53-man roster, or he will remain on the reserve/PUP list for the remainder of the 2026 season. Williams is still recovering from a torn ACL he suffered in November 2025, but he'll be eligible to suit up as early as Week 5.

Keion White

DE

questionable

Mike Evans

WR

Evans was laboring after taking a big hit from Cardinals safety Budda Baker in the second quarter of this past Sunday's win against Arizona, eventually being ruled out due to a rib injury. Afterward, Evans was diagnosed with a strained rib, but Shanahan also relayed to Vic Tafur of The Athletic on Wednesday that the wide receiver "may" practice later this week. Logging some on-field work Thursday and/or Friday seemingly will give Evans a chance to play Week 4 against the Broncos, but his upcoming availability remains up in the air.

Renardo Green

CB

With the Cardinals running 87 offensive plays, it led to inflated tackle numbers across the board for San Francisco defenders, and it was Green's second career game with double-digit tackles. Through three games this season, Green has 18 tackles (10 solo) and two pass breakups, including one interception.

Fred Warner

LB

The Cardinals ran a whopping 87 offensive plays Sunday, and Warner was on the field for all of them, leading to the inflated tackles number. The 17 tackles were the most Warner has ever recorded in a single game during his nine-year career. Through three games this season, Warner has 33 tackles (14 solo), including 0.5 sacks, two forced fumbles and one pass breakup.

Kaelon Black

RB

Black accumulated 95 scrimmage yards on 22 touches through the first two games of the season while working behind Christian McCaffrey, but the rookie observed most of Sunday's game from the sidelines, seeing the field for only eight of the 49ers' 54 offensive snaps (14.8 percent). Keeping McCaffrey healthy is a top priority, but Black's workload is likely to remain erratic and dependent on game script. The 49ers will remain home in Week 4 to host the Broncos this Sunday.

Romello Height

DE

questionable

Jacob Cowing

WR

Even though Demarcus Robinson (ankle) was moved to injured reserve following Week 2 and Mike Evans (rib) was unable to finish Sunday's contest, Cowing didn't benefit from much of a spike in playing time. In fact, after logging 24 of the 49ers' 52 offensive snaps (46.2 percent) in Week 2, Cowing saw his snap share drop to 31.5 percent. The biggest beneficiary of Robinson's absence and Evans' early exit was KhaDarel Hodge, who finished second to only Deebo Samuel (39) among 49ers receivers with 30 snaps.

Jordan Watkins

WR

Making his 2026 debut after he was a healthy inactive for the 49ers' first two contests, Watkins took the field for 15 of the team's 54 offensive snaps and was able to make a mark with 34- and 26-yard grabs. He still finished fifth among 49ers receivers in playing time, but he could see an uptick in opportunities if the rib strain Mike Evans suffered Sunday prevents him from playing Week 4 against the Broncos.

James Thompson Jr.

DT

Thompson is in line to miss a second consecutive game due to the high-ankle sprain he suffered during the Week 2 win over the Dolphins. While there's currently no timetable for his return, his next chance to play will be the Week 6 matchup against Seattle.

Nick Bosa

DE

After Bosa strained his calf at practice last Thursday, Shanahan told Matt Barrows of The Athletic that the pass rusher would miss "a few weeks," so a second consecutive absence in Week 4 comes as no surprise. The 49ers started Ogbo Okoronkwo and Keion White at defensive end during Sunday's win versus the Cardinals and likely will continue to lean on the duo until Bosa is able to return to action.

Tatum Bethune

LB

Enrique Cruz Jr.

OT

Ephesians Prysock

CB

Kurtis Rourke

QB

Eddy Pineiro

PK

Pineiro had not missed an extra point in 2026 coming into Sunday. He has nonetheless made 11 through three contests, so he's getting regular scoring opportunities in the 49ers' high-powered offense.

Deebo Samuel Sr.

WR

Samuel started off his day with a bang, receiving a lateral from fellow wideout Mike Evans during a hook-and-ladder play by San Francisco in the first quarter, taking off down the sideline for an 80-yard score. Samuel failed to catch a pass and didn't garner a target for the first time in three games this year, but he still found a way to make the most of limited opportunities. Evans suffered a rib/oblique injury in the second quarter of the victory, and if he's sidelined moving forward, Samuel will stand to operate as the team's No. 1 option at wide receiver.

George Kittle

TE

Kittle led the 49ers in receptions, receiving yards and targets on the afternoon, marking what may have been his return to both full health and a full workload following last January's Achilles tear. The veteran tight end struck from 10 and 20 yards out for his pair of fourth-quarter scoring grabs, his first multi-TD tally since Week 11 of last season. Kittle now has hit or exceeded the 80-yard mark in consecutive games, and he should remain heavily involved in a Week 4 home matchup against a Broncos defense that tends to funnel passing toward the middle of the field due to its outstanding cornerback play.

Brock Purdy

QB

Purdy's completion percentage was below his usual standards, but the fifth-year signal-caller more than made up for it with some effective downfield passing and his quartet of scoring tosses. His yardage total also got a boost from an 80-yard hook-and-lateral play in the first quarter between Mike Evans and Deebo Samuel that the latter took all the way to the house from San Francisco's 20-yard line, which served as the quarterback's first touchdown pass of the day. Purdy would go on to connect with Evans (23 yards) and George Kittle (10 and 20 yards) for his other three scoring tosses, with the final one of those coming two plays after a holding penalty on the talented tight end nullified a winding 45-yard touchdown run by the athletic quarterback. Purdy now boasts a 9:1 TD:INT and 789 passing yards over his first three games heading into a tough Week 4 home showdown against the Broncos next Sunday.

Christian McCaffrey

RB

McCaffrey's carry total was modest by his standards, but he still outpaced backup Kaelon Black by 11 rushes and four targets while also recording a one-yard touchdown run early in the third quarter. McCaffrey was highly efficient with his rushing opportunities, and he finished second in receptions and third in targets for the 49ers on the afternoon. San Francisco's pass-catching corps suffered further attrition this weekend -- Mike Evans exited the game with a rib/oblique injury, while Demarcus Robinson (ankle) was placed on injured reserve Saturday -- so McCaffrey could continue to see his receiving work creep up in a Week 4 home showdown against the Broncos next Sunday.

Trent Williams

OT

Williams was carted off the field and into the locker room during the third quarter, so he figures to be closer toward the doubtful side of returning to Sunday's contest. Vederian Lowe figures to take over at left tackle in Williams' absence.

Jack Jones

CB

Jones sustained a foot injury in the 49ers' Week 2 win over the Dolphins, but the fifth-year pro has been cleared to play in Sunday's NFC West showdown. He's logged three pass defenses and zero tackles through the first two games of the regular season while serving in a rotational role in the secondary.