NFL · 2026 · AI Picks
San Francisco 49ers
Betting picks, ATS record, and odds analysis for San Francisco 49ers. Updated daily.
100.0%
Win%
6-0
Record
-0.2u
GODDS Units
W6
Streak
GODDS Record on San Francisco 49ers
3W-3L · -0.2u
Win Rate
50%

BetAnything
35% Sports Free Play up to $105
San Francisco 49ers Betting Trends
ATS Record
4-2
66.7% cover rate
Home
4-0
100% at home
Away
2-0
100% on road
Scoring
29.5
18.3 allowed
San Francisco 49ers Injury Report
Christian Kirk
WR
Back-to-back full practices have Kirk trending in the right direction ahead of Sunday's game against the Falcons. The 49ers have until Saturday to activate Kirk from IR ahead of Week 7 action, but if he's available this weekend he'd provide a boost to a WR corps dealing with injuries to both Mike Evans (ribs/Achilles) and Deebo Samuel (hamstring).
Mike Evans
WR
Evans officially logged a second consecutive DNP after he made an early exit from Monday's win against the Commanders due to an aggravation of a right Achilles' injury, which head coach Kyle Shanahan has called soreness, per Wagoner. While Evans now has just one more chance to mix into drills this week, he's proved in the past that he doesn't require practice reps to be available on game days. Whether or not he has a chance to play Sunday in Atlanta will become known once the 49ers post their final Week 7 injury report Friday.
Jaden Dugger
LB
Dugger appears to have picked up a knee injury in the 49ers' Week 6 win over the Commanders. The strongside linebacker's ability to practice in the first Week 7 prep session is a strong sign that he should be able to suit up for Sunday's contest against the Falcons. Dugger will likely need to upgrade to full participation by Friday's session to avoid an injury designation ahead of Sunday's game.
Mykel Williams
DE
Williams likely sustained his knee injury in the 49ers' Week 6 win over the Commanders on Monday night. It is unclear how significant the defensive end's issue is. Still, he will need to achieve some level of practice participation by Friday to have any hope of suiting up for Sunday's game against the Falcons.
Nick Bosa
DE
Bosa was unable to practice for the second straight day to open the week as he continues to work his way back from a calf injury that has sidelined him since Week 2. The defensive lineman is all but guaranteed to miss a fifth straight game Sunday versus the Falcons, but the team expressed optimism that Bosa could return to action Nov. 8 against the Raiders, per Matt Zenitz of CBSSports.com.
San Francisco 49ers Pick History
Oct 19 · Washington Commanders @ San Francisco 49ers
San Francisco 49ers -7.5 -110
Oct 11 · San Francisco 49ers @ Seattle Seahawks
San Francisco 49ers +3 -100
Oct 4 · Denver Broncos @ San Francisco 49ers
Denver Broncos +2.5 -101
Sep 27 · Arizona Cardinals @ San Francisco 49ers
Arizona Cardinals +8.5 -110
Sep 20 · Miami Dolphins @ San Francisco 49ers
San Francisco 49ers -13 -115
Sep 10 · San Francisco 49ers @ Los Angeles Rams
Los Angeles Rams -3.5 -110
San Francisco 49ers Betting FAQ
The San Francisco 49ers are 6-0 this season (100.0% win rate). Currently on a W6 streak.
The San Francisco 49ers are 4-2 ATS (66.7% cover rate) this season.
GODDS is 3W-3L on San Francisco 49ers picks (6 graded), -0.2 units.
GODDS compares San Francisco 49ers odds across 8 offshore sportsbooks. Each new pick names the book with the best price at its line when it is made, if a book has that line. Our Throne ranking currently puts BetAnything, Bovada, and BetOnline.ag at the top.
Current San Francisco 49ers injury report: Christian Kirk (Injured Reserve), Mike Evans (Questionable), Jaden Dugger (Questionable).
San Francisco 49ers Picks & Betting Analysis 2026
GODDS tracks every San Francisco 49ers bet with a public win-loss record. Our AI algorithm reads the San Francisco 49ers matchups it covers on signals such as season record, ATS history, recent form, scoring edge, line movement, injuries and head-to-head data, and publishes a pick only when its model gives a side 70% or more.
The San Francisco 49ers are 6-0 this season and covering the spread at a 66.7% rate. They average 29.5 points per game and allow 18.3.
The San Francisco 49ers play at Levi's Stadium in Santa Clara, CA in the NFC West Division. Founded in 1946.
For upcoming San Francisco 49ers games, see San Francisco 49ers team page. For today's full slate, see NFL picks today.
Betting Academy
Don't just bet - understand why.
Five tracks from rookie to god. Free to start.