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Settings →NFL · 2025 · AI Picks
Betting picks, ATS record, and odds analysis for San Francisco 49ers. Updated daily.
70.6%
Win%
12-5
Record
L1
Streak

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ATS Record
Tracking
No data yet
Home
5-3
63% at home
Away
7-2
78% on road
Scoring
25.7
21.8 allowed
Nick Martin
LB
Martin was placed on IR with a concussion Dec. 20, and he was sidelined for the remainder of the season. The 2025 third-round pick tallied 11 tackles and one forced fumble across seven games as a rookie. Martin will likely once again see the majority of his playing time come on special teams while providing depth at inside linebacker.
Trent Williams
OT
Williams had his $10 million option bonus declined by San Francisco on March 20, and he currently carries a $46.3 million cap number for the 2026 season. The team likely will have to lower that number to keep the three-time All-Pro and 12-time Pro Bowler on the roster. Lynch also said he feels like the two sides are "on the precipice of something good happening, but we'll see." Williams has started all 84 regular-season games that he's played in San Francisco, and he's entering his age-38 season in 2026.
Mykel Williams
DE
Williams tore the ACL and lateral meniscus in his right knee during the 49ers' Week 9 win over the Giants. Lynch acknowledged that the 2025 first-round pick might take longer than fellow defensive end Nick Bosa, who tore his ACL about 1.5 months earlier in late September, to recover. Williams tallied 20 tackles and 1.0 sacks over nine games as a rookie.
Nick Bosa
DE
Bosa suffered a torn right ACL during Week 3 last season and underwent successful surgery in late September. The 28-year-old has been trending in a positive direction since the beginning of the offseason, and it would be a significant boost for San Francisco's defense if he's ready to go for Week 1 of the 2026 regular season. In the four seasons before 2025, Bosa logged 53.5 sacks over 64 regular-season games.
Christian McCaffrey
RB
McCaffrey earned NFL Comeback Player of the Year honors in 2025, in which he suited up for all 17 regular-season games while racking up 2,126 yards from scrimmage and 17 total touchdowns on a career-high 413 touches. Shanahan acknowledged that McCaffrey, who will turn 30 in June and was limited to just four appearances in 2024 due to Achilles and knee issues, may have had his efficiency hampered by his workhorse role in 2025, as he averaged just 3.9 YPC. Jordan James and Isaac Guerendo are current candidates to compete for an increased No. 2 role behind McCaffrey following the departure of Brian Robinson for Atlanta, but the 49ers also could make further additions to the backfield in April's draft.
No picks yet for San Francisco 49ers
GODDS will generate picks when San Francisco 49ers games are available.
View all NFL picks today →GODDS tracks every San Francisco 49ers bet with a public win-loss record. Our AI algorithm evaluates all San Francisco 49ers matchups using 18 signals — season record, ATS history, recent form, scoring edge, line movement, injuries, and head-to-head data.
The San Francisco 49ers are 12-5 this season. They average 25.7 points per game and allow 21.8.
The San Francisco 49ers play at Levi's Stadium in Santa Clara, CA in the NFC West Division. Founded in 1946.
For upcoming San Francisco 49ers games, see San Francisco 49ers team page. For today's full slate, see NFL picks today.
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