NFL · 2026 · AI Picks
San Francisco 49ers
Betting picks, ATS record, and odds analysis for San Francisco 49ers. Updated daily.
100.0%
Win%
3-0
Record
+0.8u
GODDS Units
W3
Streak
GODDS Record on San Francisco 49ers
2W–1L · +0.8u
Win Rate
67%

BetAnything
35% Sports Free Play up to $105
San Francisco 49ers Betting Trends
ATS Record
2-1
66.7% cover rate
Home
2-0
100% at home
Away
1-0
100% on road
Scoring
32.7
16.7 allowed
San Francisco 49ers Injury Report
Mike Evans
WR
Evans thus will have just one more chance to mix into drills Friday before the 49ers potentially make a ruling on his status ahead of Sunday's game against the Broncos. If Evans ends up being inhibited or sidelined this weekend, Deebo Samuel and Brandin Cooks represent the notable names that remain healthy in San Francisco's WR corps.
Brandin Cooks
WR
Cooks spent a little more than a week on San Francisco's practice squad before joining a position group that currently has two injured players on the active roster and four on injured reserve. He split time between the Saints and Bills in 2025, combining for a 24-279-0 line on 36 targets in 15 regular-season games.
Gracen Halton
DT
Halton did not return to the 49ers' Week 3 win over the Cardinals due to an ankle injury. However, his absence from Wednesday's injury report indicates that his ankle is fine, and the rookie fourth-rounder should be available for Sunday's home game against the Broncos. Halton has eight tackles (five solo) and one pass defense through the first three games of the regular season.
Mykel Williams
DE
Williams spent his first practice back with the 49ers as a limited participant. The team has until Oct. 21. to add the linebacker to the 53-man roster, or he will remain on the reserve/PUP list for the remainder of the 2026 season. Williams is still recovering from a torn ACL he suffered in November 2025, but he'll be eligible to suit up as early as Week 5.
Dre Greenlaw
LB
Greenlaw suffered a quadriceps injury late in the victory over Arizona on Sunday. Since then, he has missed two consecutive practices, so he will have another opportunity Friday to make some progress. If Greenlaw is unavailable versus Denver in Week 4, Garret Wallow may be needed to fill the void in the lineup.
San Francisco 49ers Pick History
San Francisco 49ers Betting FAQ
San Francisco 49ers Picks & Betting Analysis 2026
GODDS tracks every San Francisco 49ers bet with a public win-loss record. Our AI algorithm evaluates all San Francisco 49ers matchups using 18 signals — season record, ATS history, recent form, scoring edge, line movement, injuries, and head-to-head data.
The San Francisco 49ers are 3-0 this season and covering the spread at a 66.7% rate. They average 32.7 points per game and allow 16.7.
The San Francisco 49ers play at Levi's Stadium in Santa Clara, CA in the NFC West Division. Founded in 1946.
For upcoming San Francisco 49ers games, see San Francisco 49ers team page. For today's full slate, see NFL picks today.
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