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Settings →NFL · 2025 · AI Picks
Betting picks, ATS record, and odds analysis for San Francisco 49ers. Updated daily.
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Mac Jones
QB
The fact that Jones was out there throwing this week suggests that Brock Purdy's top backup should be good to go come training camp. Though there was some speculation this offseason that Jones could be on the move, he'll remain a valuable insurance policy at QB for the 49ers, on the heels of a 2025 regular season in which Purdy missed eight games, all of which Jones started in his place.
Brock Purdy
QB
As the coming campaign approaches, Purdy -- who has had time to move past the shoulder and toe issues he dealt with last season -- is set to work with a WR corps that welcomes a trio of key additions in Mike Evans, Christian Kirk and rookie second-rounder De'Zhaun Stribling. Also in the mix are returnees Ricky Pearsall, Jacob Cowing, Jordan Watkins and Demarcus Robinson. Meanwhile, Kittle is bouncing back from an Achilles injury, and though the star TE says that he has "a chance" to be ready for Week 1, the 49ers may need to lean more on their key wideouts out of the gate this year while Kittle works his way back into the mix. Purdy is coming off a 2025 regular season in which he threw for 2,167 yards with 20 TDs and 10 picks, while carrying 33 times for 147 yards and three scores in nine games. Looking ahead, the signal-caller's fantasy upside in 2026 hinges largely on avoiding injuries, as well as building strong on-field chemistry with his team's re-tooled pass-catching unit.
Brandon Aiyuk
WR
That said, it's unclear whether the Commanders would have interest in signing Aiyuk in such a scenario. Moreover, it's not a situation they can publicly comment on, given that the wideout is still under contract with the 49ers. Back in January, 49ers GM John Lynch said that it was "safe to say that (Aiyuk) has played his last snap with the Niners." However, since then the team has held on to the 2020 first-rounder in the hopes of finding a trade partner. San Francisco's veteran players are set to arrive at training camp July 25, with the report suggesting that it's possible the team is waiting until then to make a call on Aiyuk's status with the franchise.
George Kittle
TE
Kittle hedged his answer, saying he "has a chance" to be ready for the start of the regular season, but the veteran tight end has been open about the fact that he's targeting a Week 1 return, as have head coach Kyle Shanahan and GM John Lynch. Per Florito Maniego of NBC Sports Bay Area, Kittle said Monday that he's already resumed running and has been clocked at over 16 miles an hour, which is a notable step in his recovery an Achilles' tear initially suffered Jan. 11. Throughout spring practices and mandatory minicamp, Kittle worked on the side and with trainers, but it's possible he could be ready to ramp up his activity level during training camp in July.
Ricky Pearsall
WR
Pearsall is positioned for a significant role after injuries limited him to nine regular-season appearances in 2025. With Jauan Jennings having signed with the Vikings and Brandon Aiyuk seemingly out of the picture, the 25-year-old clearly projects as Brock Purdy's No. 2 wide receiver behind Evans. Christian Kirk is expected to handle slot duties, while rookie second-round pick De'Zhaun Stribling and Demarcus Robinson provide depth, but it's Pearsall and Evans who project to see the field in 21 personnel sets, which the 49ers deployed at a league-high rate in 2025. A healthy season would position Pearsall for the biggest workload of his NFL career.
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GODDS will generate picks when San Francisco 49ers games are available.
View all NFL picks today →GODDS tracks every San Francisco 49ers bet with a public win-loss record. Our AI algorithm evaluates all San Francisco 49ers matchups using 18 signals — season record, ATS history, recent form, scoring edge, line movement, injuries, and head-to-head data.
The San Francisco 49ers play at Levi's Stadium in Santa Clara, CA in the NFC West Division. Founded in 1946.
For upcoming San Francisco 49ers games, see San Francisco 49ers team page. For today's full slate, see NFL picks today.
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