NFL · 2026 · AI Picks
San Francisco 49ers
Betting picks, ATS record, and odds analysis for San Francisco 49ers. Updated daily.
87.5%
Win%
7-1
Record
-0.2u
GODDS Units
W1
Streak
GODDS Record on San Francisco 49ers
3W-3L · -0.2u
Win Rate
50%

BetAnything
35% Sports Free Play up to $105
San Francisco 49ers Betting Trends
ATS Record
5-3
62.5% cover rate
Home
5-0
100% at home
Away
2-1
67% on road
Scoring
29.4
19.5 allowed
San Francisco 49ers Injury Report
Dre Greenlaw
LB
Greenlaw had eight tackles in Sunday's win over the Raiders. While he was limited Thursday, he has more time to get cleared to suit up versus the Cowboys in Week 10. If Greenlaw can't get on the field, Jaden Dugger and Garret Wallow are both in line for more snaps.
Mike Evans
WR
Shanahan's comments signal the 49ers are taking an extra cautious approach with the veteran wideout in the hopes that he'll be available down the home stretch of the season. While Evans hasn't officially been ruled out for Sunday's game at Dallas, he isn't expected to suit up in Week 10, per Brooke Evans of the 49ers' official site. Until he's fully recovered and ready to go again, his absence should continue to open up additional opportunities outside for 2025 fourth-rounder Jordan Watkins.
Deebo Samuel Sr.
WR
Samuel has managed back-to-back capped sessions to kick off Week 10 prep as he vies for his first game action since Week 5 at Seattle, when he injured his right hamstring. Friday's injury report will reveal his odds to suit up Sunday in Dallas.
Jaden Dugger
LB
Dugger set the tone for the 49ers right out of halftime, when he intercepted a pass from Kirk Cousins intended for Tre Tucker and returned it 35 yards for a pick-six for the first defensive touchdown of Dugger's young NFL career. The rookie fifth-rounder has logged at least six solo tackles in three of his last four games and is up to 36 tackles (25 solo), including 1.0 sacks, and one pick-six through eight regular-season games.
Trent Williams
OT
Williams presumably sustained a shoulder injury in Week 9 versus the Raiders, and now his availability for Week 10 is in some doubt. If he can't log a full practice Friday, there's a chance he could end up carrying an injury designation into the weekend.
San Francisco 49ers Pick History
Oct 19 · Washington Commanders @ San Francisco 49ers
San Francisco 49ers -7.5 -110
Oct 11 · San Francisco 49ers @ Seattle Seahawks
San Francisco 49ers +3 -100
Oct 4 · Denver Broncos @ San Francisco 49ers
Denver Broncos +2.5 -101
Sep 27 · Arizona Cardinals @ San Francisco 49ers
Arizona Cardinals +8.5 -110
Sep 20 · Miami Dolphins @ San Francisco 49ers
San Francisco 49ers -13 -115
Sep 10 · San Francisco 49ers @ Los Angeles Rams
Los Angeles Rams -3.5 -110
San Francisco 49ers Betting FAQ
The San Francisco 49ers are 7-1 this season (87.5% win rate). Currently on a W1 streak.
The San Francisco 49ers are 5-3 ATS (62.5% cover rate) this season.
GODDS is 3W-3L on San Francisco 49ers picks (6 graded), -0.2 units.
GODDS compares San Francisco 49ers odds across 8 offshore sportsbooks. Each new pick names the book with the best price at its line when it is made, if a book has that line. Our Throne ranking currently puts BetAnything, Bovada, and BetOnline.ag at the top.
Current San Francisco 49ers injury report: Dre Greenlaw (Questionable), Mike Evans (Questionable), Deebo Samuel Sr. (Questionable).
San Francisco 49ers Picks & Betting Analysis 2026
GODDS tracks every San Francisco 49ers bet with a public win-loss record. Our AI algorithm reads the San Francisco 49ers matchups it covers on signals such as season record, ATS history, recent form, scoring edge, line movement, injuries and head-to-head data, and publishes a pick only when its model gives a side 70% or more.
The San Francisco 49ers are 7-1 this season and covering the spread at a 62.5% rate. They average 29.4 points per game and allow 19.5.
The San Francisco 49ers play at Levi's Stadium in Santa Clara, CA in the NFC West Division. Founded in 1946.
For upcoming San Francisco 49ers games, see San Francisco 49ers team page. For today's full slate, see NFL picks today.
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